عنوان مقاله [English]
This work is related to optimize the porous structure nanocomposites based on polypropylene fumarate/ hydroxyethyl methacrylate/ bioactive glass nanoparticles (PPF/HEMA/NBG) which are cross-linked through the Reduction-Oxidation reaction (free radical polymerization) at the room temperature. The porous structures prepared by immersion of the nanocomposites in simulated body fluid (SBF) for 4 weeks. The samples were optimized based on the PPF/HEMA ratio, the NBG content and percentage of the benzoyl peroxide and dimethyl aniline pairs (BPO+DMA) with mechanical strength (compressive strength) and surface morphology (SEM images) analyses. Finally, the best structure based on mentioned factors, SPHB.732/1.5, which contains the PPF/HEMA ratio at 30/70, NBG content at 20 wt% and BPO+DMA pairs at 1.5 wt% was introduced as the optimum structure. This structure has an elastic modulus of 57.7 Mpa, interconnected-open porous architecture with the pore size approximately 100-200μm and the surface coated with hydroxycarbonate apatite microparticles (HCA). The SPHB.732/1.5 structure prepared by soaking in SBF not only is a bioactive component but also is a biodegradable material and hence can be used as a bone scaffold when more evaluate for this application.
1. Yao CH, Tsai HM, Chen YS, Liu BS. Fabrication and evaluation of a new composite composed of tricalcium phosphate, gelatin, and Chinese medicine as a bone substitute. Journal of Biomedical Materials Research Part B: Applied Biomaterials 2005;75:277-88.
 Jones JR. Review of bioactive glass: from Hench to hybrids. Acta biomaterialia 2013;9:4457-86.
 Boccaccini AR, Erol M, Stark WJ, Mohn D, Hong Z, Mano JF. Polymer/bioactive glass nanocomposites for biomedical applications: a review. Composites Science and Technology 2010;70:1764-76.
 Shin H, Jo S, Mikos AG. Biomimetic materials for tissue engineering. Biomaterials 2003;24:4353-64.
 Rezwan K, Chen Q, Blaker J, Boccaccini AR. Biodegradable and bioactive porous polymer/inorganic composite scaffolds for bone tissue engineering. Biomaterials 2006;27:3413-31.
 Kokubo T, Kim H-M, Kawashita M. Novel bioactive materials with different mechanical properties. Biomaterials 2003;24:2161-75.
 Jarcho M. Calcium phosphate ceramics as hard tissue prosthetics. Clinical orthopaedics and related research 1981;157:259-78.
 LeGeros RZ. Calcium phosphate-based osteoinductive materials. Chemical reviews 2008;108:4742-53.
 Loher S, Reboul V, Brunner TJ, Simonet M, Dora C, Neuenschwander P, et al. Improved degradation and bioactivity of amorphous aerosol derived tricalcium phosphate nanoparticles in poly (lactide-co-glycolide). Nanotechnology 2006;17:2054.
 Misra SK, Mohn D, Brunner TJ, Stark WJ, Philip SE, Roy I, et al. Comparison of nanoscale and microscale bioactive glass on the properties of P (3HB)/Bioglass composites. Biomaterials 2008;29:1750-61.