Skin tissue serves as the body’s first defense barrier. Since this tissue is the most superficial one in the body, it is susceptible to damages from many incidents. Skin staples are one of the tools used in medicine to connect skin grafts. The purpose of this research is to make a degradable polymer skin stapler that uses electrospinning as an alternative to extruding and injecting into a mold. Physicochemical tests were done to determine the properties of the manufactured PLGA fibers. Silica nanoparticles SBA-15 made by hydrothermal method were added to improve the mechanical properties of polymer fibers. Then, FTIR test was carried out to detect the presence of nanoparticles in the polymer. The BET test was also performed to measure the size of the pores of SBA-15 silica nanoparticles as 6.77 nm, which is a confirmation of the mesoporous nature of the nanoparticles. To investigate the morphology of the electrospun fibers and silica nanoparticles, SEM image was used according to which, the average diameter of fibers and average diameter of nanoparticles were obtained as 400-500 nm and 185 nm, respectively. The results obtained from addition of SBA_15 silica nanoparticles to polymer fibers and those from comparing its mechanical properties with pure PLGA polymer fibers indicated that incorporating 1% SBA_15 silica nanoparticles into polymer improved its mechanical properties over pure polymer fibers, while fibers with 3% Silica nanoparticles showed SBA_15 comparable results. According to cytotoxicity investigation, no toxicity was observed in any group, and all groups supported the cell growth.