مواد و فناوری‌های پیشرفته

مواد و فناوری‌های پیشرفته

سنتز و مشخصه‌یابی میکروکره‌های سیلیکای متخلخل با پوشش CuO: سیستم دارورسانی ضدباکتری

نوع مقاله : مقاله کامل پژوهشی

نویسندگان
علیرضا کوهی کار 1
مریم تاج آبادی 2
1 دانشجوی کارشناسی ارشد، دانشکده‌ی مواد و متالورژی، دانشگاه علم و صنعت ایران، تهران، ایران
2 استادیار، دانشکده‌ی مواد و متالورژی، دانشگاه علم و صنعت ایران، تهران، ایران
10.30501/jamt.2025.520186.1327
چکیده
عفونت‌های باکتریایی از علل اصلی مرگ در جهان به شمار می‌روند و استفاده‌ی بیش از حد از آنتی‌بیوتیک‌ها به بروز مقاومت در برابر آن‌ها منجر شده است. پژوهش‌های نوین با بهره‌گیری از سیستم‌های دارورسانی سرامیکی زیست‌سازگار در تلاش هستند تا کارایی آنتی‌بیوتیک‌ها در برابر باکتری‌های مقاوم را بهبود بخشند. در این پژوهش، هدف اصلی بررسی پوشش‌دهی موفق نانوذرات اکسید مس (CuO) بر روی سطح میکروکره‌های سیلیکای مزومتخلخل و ارزیابی خواص ضدباکتریایی آن است. سیستم CuO@SiO₂ سنتزشده با استفاده از آزمون‌های مشخصه‌یابی متعددی نظیر XRD، FTIR، SEM، EDS و آزمایش آنتی‌باکتریال ارزیابی شد. در آزمون XRD، برخلاف نمونه‌ی آمورف سیلیکا، نمونه‌ی CuO@SiO₂ دارای پیک‌های مشخصه در زوایای 36/5، 39/5 و 68/2 درجه (بر حسب θ2) به‌ترتیب متعلق به صفحات کریستالی (002)، (111) و (202) بوده و اندازه‌ی کریستالیت ذرات CuO حدود 17 نانومتر اندازه‌گیری شد. تصاویر FESEM ریخت‌شناسی کروی و اندازه‌ی میکرو (حدود 1/2 میکرومتر) و ساختار متخلخل نمونه را تأیید کردند و آزمون EDX حضور 4 تا 13 درصد وزنی عنصر مس را در سامانه نشان داد؛ تصاویر نقشه‌برداری عنصری نیز توزیع یکنواخت و منظم این عنصر را در ساختار تأیید کرد. آزمون آنتی‌باکتریال (روش شمارش کلونی) کشندگی بالای 99 درصد را بر روی هر دو گونه‌ی باکتری E. coli و S. aureus پس از 24 ساعت برای نمونه‌ی CuO@SiO₂ نشان داد. این سامانه‌ی دارورسانی، به‌دلیل ساختار متخلخل و قابلیت ضدباکتریایی، به‌عنوان یک حامل میکرواندازه‌ی مناسب برای درمان عفونت‌ها و زخم‌های مختلف، با امکان بارگذاری انواع داروها، پتانسیل بالایی برای افزایش اثربخشی درمان دارد.
کلیدواژه‌ها
سیلیکای متخلخل
اکسید مس
میکروکره
ضد باکتری
دارورسانی

موضوعات

عنوان مقاله English

Synthesis and Characterization of Porous Silica Microspheres Capped with CuO: Antibacterial Drug Delivery System

نویسندگان English

Alireza Koohikar 1
Maryam Tajabadi 2
1 MSc Student, School of Materials and Metallurgical Engineering, Iran University of Science and Technology, Tehran, Iran.
2 Assistant Professor, School of Materials and Metallurgical Engineering, Iran University of Science and Technology, Tehran, Iran.
چکیده English

Bacterial infections remain a leading cause of mortality worldwide, exacerbated by the overuse of antibiotics, which has driven the emergence of antimicrobial resistance. Recent advancements in biocompatible ceramic drug delivery systems aim to enhance antibiotic efficacy against resistant bacteria. This study focuses on the successful coating of copper oxide (CuO) nanoparticles onto mesoporous silica microspheres and the evaluation of their antibacterial properties. The synthesized CuO@SiO₂ system was characterized using various techniques, including X-ray diffraction (XRD), Fourier-transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDS), and antibacterial assays. XRD analysis revealed distinct peaks for CuO@SiO₂ at 36.5°, 39.5°, and 68.2° (2θ), corresponding to the (002), (111), and (202) crystal planes, respectively, with a crystallite size of approximately 17 nm, in contrast to the amorphous silica structure. FESEM images confirmed the spherical morphology, microscale size (~1.2 µm), and porous structure of the samples, while EDS analysis indicated a copper content of 4–13 wt%, with elemental mapping demonstrating uniform copper distribution. Antibacterial testing (colony counting method) exhibited over 99% bacterial inhibition against both Escherichia coli and Staphylococcus aureus after 24 hours for CuO@SiO₂. Owing to its porous structure and potent antibacterial activity, this microscale drug delivery system shows significant potential as a versatile carrier for various therapeutic agents, enhancing treatment efficacy for infections and wound healing applications.

کلیدواژه‌ها English

Porous Silica
CuO
Microspheres
Antibacterial
Drug Delivery
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مواد و فناوری‌های پیشرفته
دوره 14، شماره 1
بهار 1404
صفحه 77-88

  • تاریخ دریافت 21 اردیبهشت 1404
  • تاریخ بازنگری 09 تیر 1404
  • تاریخ پذیرش 11 مرداد 1404