This study explores a carrageenan-Gallic acid scaffold incorporating halloysite nanotubes loaded with erythromycin for potential applications in skin tissue engineering. In this regard, erythromycin was encapsulated within halloysite nanotubes, and scaffolds containing 1, 3, and 5 wt% carrageenan were fabricated using the freeze-drying technique. The physicochemical and biological properties of the scaffolds were evaluated through scanning electron microscopy (SEM), Fourier-transform infrared spectroscopy (FTIR), mechanical strength assessment, water absorption capacity, degradation rate analysis, antibacterial activity, antioxidant properties, and fibroblast cell viability and migration assays. According to the SEM results, the porosity percentages of the scaffolds containing 1, 3, and 5 wt% carrageenan were calculated as 62.43±1.8%, 69.28±2.1%, and 71.28±3.9%, respectively. An increase in carrageenan content led to a rise in pore size and porosity, which consequently enhanced water absorption, accelerated degradation, and improved fibroblast cell viability and migration. However, a reduction in compressive strength and Young’s modulus was observed. The antibacterial evaluation demonstrated that the scaffold with 5 wt% carrageenan exhibited superior antibacterial efficacy due to increased drug release. Additionally, the antioxidant analysis revealed that the scaffold containing 1 wt% carrageenan exhibited the highest antioxidant activity, which was attributed to the greater release of Gallic acid. Overall, the scaffold with 5 wt% carrageenan demonstrated optimal biocompatibility, superior antibacterial properties, and enhanced fibroblast viability and migration, making it a promising candidate for skin tissue engineering applications.