مواد و فناوری‌های پیشرفته

مواد و فناوری‌های پیشرفته

بررسی اثر افزودن ذرات هیدروکسی آپاتیت و نانولوله‌های کربنی بر خواص مکانیکی و زیستی کامپوزیت کیتوسان/ ژلاتین

نوع مقاله : مقاله کامل پژوهشی

نویسندگان
سمانه نیک پر 1
علیرضا خاوندی 2
جعفر جوادپور 2
حمیدرضا رضایی 2
1 دانشجوی کارشناسی ارشد، دانشکده‌ی مواد و متالورژی، دانشگاه علم و صنعت ایران، تهران، ایران
2 استاد، دانشکده‌ی مواد و متالورژی، دانشگاه علم و صنعت ایران، تهران، ایران
10.30501/jamt.2025.500143.1317
چکیده
در این پژوهش، هیدروژل‌های کامپوزیتی ژلاتین/ کیتوسان با استفاده از روش خشک ‌کردن انجمادی تهیه شدند و تأثیر افزودن مقادیر مختلف وزنی هیدروکسی ‌آپاتیت (1، 2 و 3 درصد وزنی) و نانولوله‌های کربنی چندجداره‌ی عامل‌دارشده (0/2، 0/3 و 0/4 درصد وزنی) بر ریزساختار، خواص مکانیکی و زیستی هیدروژل‌ها بررسی شد. نتایج میکروسکوپ الکترونی روبشی (SEM) نشان داد که با افزایش غلظت هیدروکسی ‌آپاتیت، اندازه‌ی منافذ کاهش چشمگیری یافت، به‌طوری ‌که اندازه‌ی منافذ از 5/53 ± ۲۲۱ میکرومتر در غلظت 1 درصد وزنی به 2/93 ± ۱۱۷ و 2 ± ۸۰ میکرومتر در غلظت‌های ۲ و ۳ درصد وزنی کاهش یافت. با افزایش غلظت نانولوله‌های کربنی در غلظت‌های 0/3 و 0/4 درصد وزنی، اندازه‌ی منافذ از 5/53 ± ۲۲۱ میکرومتر به 4/64 ± ۱۸۵ و 3/61 ± ۱۴۴ میکرومتر کاهش یافت. نتایج آزمون‌های مکانیکی نشان داد که با افزایش مقادیر هیدروکسی ‌آپاتیت و نانولوله‌های کربنی، مدول یانگ به‌طور معناداری افزایش یافت، به‌طوری ‌که از 0/05 ± 1/09 مگاپاسکال به 0/22 ± 4/92 مگاپاسکال و 0/13 ± 2/90 مگاپاسکال رسید. همچنین، ظرفیت تورم و نرخ تخریب با افزایش غلظت ذرات کاهش یافت. نتایج آزمون‌های سمیت سلولی نشان داد که هیدروژل‌های انتخاب‌شده هیچ‌گونه سمیت سلولی ندارند و می‌توانند از رشد و تکثیر سلول‌ها حمایت ‌کنند.
کلیدواژه‌ها
هیدروژل کیتوسان/ ژلاتین
هیدروکسی آپاتیت
نانولوله‌های کربنی

موضوعات

عنوان مقاله English

Investigation of the Effects of Hydroxyapatite Particles and Carbon Nanotubes on the Mechanical and Biological Properties of Chitosan/Gelatin Composites

نویسندگان English

Samaneh Nikpar 1
Alireza Khavandi 2
Jafar Javadpour 2
Hamidreza Rezaie 2
1 MSc Student, School of Materials and Metallurgical Engineering, Iran University of Science and Technology, Tehran, Iran.
2 Professor, School of Materials and Metallurgical Engineering, Iran University of Science and Technology, Tehran, Iran.
چکیده English

In this study, gelatin/chitosan hydrogels were synthesized using polymer casting and freeze-drying techniques. The effects of varying concentrations of hydroxyapatite (HA) particles and carbon nanotubes (CNTs) on the mechanical and biological properties of the scaffolds were investigated. Scanning Electron Microscopy (SEM) images showed that increasing the concentrations of HA and CNTs resulted in a reduction of the average pore size from 221 ± 5.53 µm to 80 ± 2 µm and 144 ± 3.61 µm, respectively. Water absorption capacity decreased from 2516% to 1367% and 1509% upon increasing HA and CNT content, respectively. Furthermore, the degradation rate of the scaffolds under in vitro conditions was reduced followed by the addition of nanoparticles. Compressive strength tests revealed that the Young’s modulus increased from 1.09 ± 0.05 MPa up to 4.92 ± 0.22 MPa and 2.90 ± 0.13 MPa as the HA and CNT concentrations increased, respectively. These findings suggest that gelatin/chitosan hydrogels containing HA particles and CNTs exhibit desirable microstructural properties, including uniform distribution of interconnected pores, enhanced swelling capacity, and improved mechanical performance, making them promising candidates for tissue engineering applications.

کلیدواژه‌ها English

Chitosan/Gelatin Hydrogel
Hydroxyapatite
Carbon Nanotubes
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مواد و فناوری‌های پیشرفته
دوره 13، شماره 4
زمستان 1403
صفحه 73-85

  • تاریخ دریافت 02 بهمن 1403
  • تاریخ بازنگری 19 اسفند 1403
  • تاریخ پذیرش 19 فروردین 1404