مواد و فناوری‌های پیشرفته

مواد و فناوری‌های پیشرفته

طراحی و بهینه‌سازی سامانه‌ی نیوزومی با بارگذاری هم‌زمان داروهای جمسیتابین و کورکومین به‌منظور کاربرد در شیمی‌درمانی سرطان

نوع مقاله : مقاله کامل پژوهشی

نویسندگان
امین رحیمی نژاد 1
مژگان حیدری 2
فریبا تاج آبادی 2
1 دانشجوی دکتری، پژوهشکده‌ی فناوری نانو و مواد پیشرفته، پژوهشگاه مواد و انرژی، کرج، ایران
2 دانشیار، پژوهشکده‌ی فناوری نانو و مواد پیشرفته، پژوهشگاه مواد و انرژی، کرج، ایران
10.30501/jamt.2025.506719.1320
چکیده
سرطان پانکراس ازجمله بیماری‌های با مرگ‌ومیر بالا در جهان محسوب می‌شود و تلاش‌های بسیاری برای درمان این بیماری انجام شده است. ازجمله داروهای بسیار تأثیرگذار در این بیماری داروی جمسیتابین است. این دارو نیمه‌عمر کوتاهی دارد و پس از مدتی مقاومت دارویی ایجاد می‌کند. به‌منظور بهبود عملکرد این دارو نیاز است تا از حامل برای آن استفاده شود و همچنین داروی دیگری با نام کورکومین هم‌زمان استفاده شود تا تأثیر آن را افزایش دهد. استفاده از سامانه‌های دارورسانی نوین می‌تواند در رفع این چالش مؤثر باشد. به همین منظور، در این تحقیق از سامانه‌ی وزیکولی نیوزومی به‌منظور بارگذاری هم‌زمان دو دارو استفاده شد. به‌منظور طراحی سامانه‌ی مطلوب و مهندسی‌شده، آزمون‌های مختلفی انجام شد. نتایج نشان داد نسبت بهینه‌ی لیپید به دارو باید 20 باشد. همچنین، زمان پخش کردن با فراصوت بهینه حدود 24 دقیقه انتخاب شد که حاصل آن نیوزوم‌هایی با اندازه‌ی 241 نانومتر بود که برای عبور از منافذ بین‌یاخته‌ای سلول‌های سرطانی بسیار مناسب است. تصاویر SEM نیز نشان‌دهنده‌ی کروی بودن و تشکیل وزیکول‌ها بود. با بهینه‌سازی پارامترهای مؤثر در ساخت، بارگذاری برای داروی کورکومین به 93 درصد و برای داروی جمسیتابین به 65 درصد رسید. میزان رهایش داروها در بارگذاری هم‌زمان پس از 48 ساعت برای جمسیتابین 38 درصد و برای کورکومین 13/5 درصد به دست آمد. نتایج حاصل از این مطالعه نشان داد که سیستم دارورسانی نیوزومی با بارگذاری هم‌زمان داروهای جمسیتابین و کورکومین به‌منظور کاربرد در شیمی‌درمانی سرطان مناسب است.
کلیدواژه‌ها
نانونیوزوم
کورکومین
جمسیتابین
رهایش هم‌زمان
رهایش دارو

موضوعات

عنوان مقاله English

Design and Optimization of a Niosomal System with Simultaneous Loading of Gemcitabine and Curcumin Drugs for Applications in Cancer Chemotherapy

نویسندگان English

Amin Rahiminejad 1
Mojgan Heydari 2
Fariba Tajabadi 2
1 PhD Student, Department of Nano Technology and Advanced Materials, Materials and Energy Research Center, Karaj, Iran.
2 Associate Professor, Department of Nano Technology and Advanced Materials, Materials and Energy Research Center, Karaj, Iran.
چکیده English

Pancreatic cancer exhibits a high mortality rate globally, and numerous research efforts have been directed toward treating this disease. Gemcitabine is considered one of the most efficacious pharmacological agents for the treatment of this disease. However, this drug is characterized by its short half-life and development of resistance over time. To enhance the efficacy of this drug, it is imperative to utilize a carrier and concurrently administer another drug, Curcumin, to augment its effect. The implementation of advanced drug delivery systems can effectively address this challenge. For this purpose, a niosomal vesicle system was employed to simultaneously encapsulate both drugs. Various assays were conducted to design optimal and engineered systems. The results demonstrated that the optimal lipid-to-drug ratio was 20. Furthermore, the optimal sonication time was determined to be approximately 24 minutes, yieldeding niosomes with a diameter of 241 nm, suitable for passing through the intercellular pores of cancer cells. FESEM images also confirmed the semi-sphericity and formation of vesicles. Through optimization of the effective parameters in the synthesis process, the encapsulation efficiency for Curcumin reached 93%, while that for Gemcitabine reached 65%. The drug release rate after 48 h of co-encapsulation was 38% for Gemcitabine and 13.5% for Curcumin. The results of this study indicate that the niosomal drug delivery system with simultaneous loading of Gemcitabine and Curcumin is suitable for use in cancer chemotherapy.

کلیدواژه‌ها English

Nano Niosome
Curcumin
Gemcitabine
Co-delivery
Drug Delivery
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مواد و فناوری‌های پیشرفته
دوره 13، شماره 4
زمستان 1403
صفحه 57-72

  • تاریخ دریافت 30 بهمن 1403
  • تاریخ بازنگری 13 اسفند 1403
  • تاریخ پذیرش 28 اسفند 1403