مواد و فناوری‌های پیشرفته

مواد و فناوری‌های پیشرفته

زخم‌پوش‌های بر پایه‌ی پکتین

نوع مقاله : مقاله مروری پژوهشی

نویسندگان
پگاه پورخلیلی 1
ژامک نورمحمدی 2
معصومه حق‌بین نظرپاک 3
1 دانشجوی کارشناسی ارشد، دانشکدگان علوم و فناوری‌های میان‌رشته‌ای، دانشگاه تهران، ایران
2 دانشیار، دانشکدگان علوم و فناوری‌های میان‌رشته‌ای، دانشگاه تهران، ایران
3 استادیار، مرکز تحقیقات فناوری‌های نو، دانشگاه صنعتی امیرکبیر، تهران، ایران
10.30501/jamt.2025.484957.1308
چکیده
روند بهبود زخم شامل چهار مرحله‌ی هموستاز، التهاب، تکثیر و بازسازی است. بسیاری از پانسمان‌های زخم برای تقویت توانایی بدن در بستن زخم‌ها و بازگرداندن عملکرد بافت‌های آسیب‌دیده طراحی شده‌اند. پکتین به‌دلیل سازوکار ژل‌سازی ساده و سازگاری با سلول به‌تازگی برای کاربردهای گوناگون زیست‌پزشکی ازجمله ترمیم زخم استفاده شده است. ذرات پکتین آب‌دوست در داخل زخم‌پوش با مایع زخم واکنش می‌دهند و ژل نرمی‌‌ را روی بستر زخم تشکیل می‌‌دهند و درنتیجه ترشحات زخم را جذب می‌کنند. همچنین، محیط اسیدی به‌دست‌آمده با حل شدن پکتین ممکن است به‌عنوان مانعی باکتریایی یا ویروسی عمل کند. در این تحقیق، مطالعات اخیر مربوط به پکتین در زمینه‌ی زیست‌پزشکی، که خارج از زمینه‌های کاربردی سنتی مانند صنایع غذایی یا داروسازی هستند، مرور می‌شوند. همچنین، درباره‌ی ساختار پکتین و روش‌های استخراج با تمرکز بر خواص پلی‌ساکارید بحث شده است که می‌‌تواند ژل‌ها را برای کاربرد مورد نظر بهینه کند و نقش اساسی در کاربرد پکتین در زمینه‌ی زیست‌پزشکی داشته باشد. در ادامه، روش‌های گوناگون ایجاد کراس‌لینک در ساختار پکتین برای کاربردهای پزشکی معرفی و مزایا و معایب هر روش بیان شد. درباره‌ی نقش الیاف الکتروریسی‌شده‌ی پکتین برای کاربردهای ترمیم زخم نیز به‌طور ویژه بحث شده است.
کلیدواژه‌ها
زخم‌پوش
پکتین
هیدروژل
نانوالیاف

موضوعات

عنوان مقاله English

Wound Dressings Based on Pectin

نویسندگان English

Pegah Poorkhalili 1
Jhamak Nourmohammadi 2
Masoumeh Haghbin Nazarpak 3
1 MSc Student, College of Interdisciplinary Science and Technology, University of Tehran, Iran
2 Associate Professor, College of Interdisciplinary Science and Technology, University of Tehran, Iran
3 Assistant Professor, New Technologies Research Center (NTRC), Amirkabir University of Technology (AUT), Tehran, Iran
چکیده English

The wound healing process consists of four stages: hemostasis, inflammation, proliferation, and remodeling. Many wound dressings are designed to enhance the body’s ability to close wounds and restore the function of damaged tissues. Recently, pectin has been utilized for various biomedical applications, including wound healing, due to its simple gel-forming mechanism and cell compatibility. The hydrophilic pectin particles in the dressing interact with wound exudate to form a soft gel layer on the wound bed, effectively absorbing exudates. Additionally, the acidic environment created by the dissolution of pectin may serve as a barrier against bacteria and viruses. This study reviews recent research on pectin for biomedical applications, extending beyond traditional uses in food or pharmaceuticals. It discusses the structure of pectin and extraction methods, focusing on the polysaccharide properties that can optimize gels for specific applications, thereby playing a crucial role in its biomedical use. Various crosslinking methods for pectin structures in medical applications are introduced, along with their respective advantages and disadvantages. The role of electrospun pectin fibers in wound healing applications is also specifically addressed.

کلیدواژه‌ها English

Wound Dressing
Pectin
Hydrogel
Nanofibers
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مواد و فناوری‌های پیشرفته
دوره 13، شماره 4
زمستان 1403
صفحه 40-56

  • تاریخ دریافت 28 آبان 1403
  • تاریخ بازنگری 04 دی 1403
  • تاریخ پذیرش 13 اسفند 1403