مواد و فناوری‌های پیشرفته

مواد و فناوری‌های پیشرفته

بررسی اثر نسبت اجزای فاز مایع بر زمان گیرش و استحکام سیمان استخوانی پلی‌متیل متاکریلات

نوع مقاله : مقاله کامل پژوهشی

نویسندگان
نادر نظافتی 1
سعید حصارکی 2
شکوفه برهان 3
1 دانشیار، پژوهشکده‌ی فناوری نانو و مواد پیشرفته، پژوهشگاه مواد و انرژی، کرج، ایران
2 استاد، پژوهشکده‌ی فناوری نانو و مواد پیشرفته، پژوهشگاه مواد و انرژی، کرج، ایران
3 استادیار، گروه مهندسی مواد، شیمی و پلیمر، مرکز آموزش عالی فنی و مهندسی بوئین‌زهرا، قزوین، ایران
10.30501/jamt.2025.499806.1316
چکیده
در این تحقیق، تأثیر نسبت اجزای مختلف فاز مایع بر خواص سیمان استخوانی پلی‌متیل متاکریلات بررسی شد. میکروسفرهای پلی‌متیل متاکریلات به روش امولسیونی سنتز شدند. مشاهدات میکروسکوپ الکترونی روبشی نشان داد که میکروسفرهایی با اندازه‌ی 20 میکرومتر به دست آمده است. سیمان استخوان بهینه‌شده از نظر استحکام مکانیکی و زمان گیرش، با تغییر نسبت مولی متیل متاکریلات (به‌عنوان مونومر)، بنزوئیل پراکسید (به‌عنوان آغازگر) و متیل تولوئیدین (به‌عنوان فعال‌کننده) به دست آمد. حضور بنزوئیل پراکسید، متیل تولوئیدین و هیدروکینون (به‌عنوان عامل بازدارنده‌ی واکنش) با طیف‌سنجی تبدیل فوریه تأیید شد. زمان گیرش از 10 دقیقه تا 24 ساعت و مقاومت فشاری و مدول الاستیک به‌ترتیب از 7 تا 60 مگاپاسکال و 0/15 تا 0/88گیگاپاسکال بود. نتایج آنالیز دماسنجی نشان داد که گرمای واکنش سیمان‌ها با افزایش نسبت مولی بنزوئیل پراکسید به متیل تولوئیدین افزایش می‌یابد. آنالیز فازی سیمان استخوانی بهینه‌شده وجود هر دو فاز آمورف و بلوری مربوط به متیل متاکریلات را تأیید کرد. مطالعات سلولی نشان داد که سیمان غیرسمی است و سلول‌های فیبروبلاست چسبندگی مناسبی روی سطح نشان دادند. با توجه به نتایج، این سیمان می‌تواند برای درمان آسیب‌های ستون‌فقرات مانند ورتبروپلاستی و کایفوپلاستی مناسب باشد.
کلیدواژه‌ها
سیمان استخوانی پلی متیل متااکریلات
فاز مایع
خواص مکانیکی
گرمای واکنش
سمیت سلولی

موضوعات

عنوان مقاله English

The Role of Various Ratios of Liquid Phase Constituents on the Setting Time and Strength of Polymethyl Methacrylate Bone Cement

نویسندگان English

Nader Nezafati 1
Saeed Hesaraki 2
Shokoufeh Borhan 3
1 Associate professor, Department of Nanotechnology and Advanced Materials, Materials and Energy Research Center, Karaj, Iran.
2 Professor, Department of Nanotechnology and Advanced Materials, Materials and Energy Research Center, Karaj, Iran.
3 Assistant professor, Department of Chemical and Materials Engineering, Technical University of Buein Zahra, Qazvin, Iran.
چکیده English

In this study, the effect of the ratio of different components of the liquid phase on the properties of polymethyl methacrylate bone cement was investigated. Polymethyl methacrylate microspheres were synthesized through the emulsion method. Scanning electron microscope observations showed that microspheres with a size of 20 microns were obtained. The optimized bone cement, in terms of mechanical strength and setting time, was achieved by changing the molar ratio of methyl methacrylate (as monomer), benzoyl peroxide (as an initiator), and methyl toluene (as an activator). The presence of benzoyl peroxide, methyl toluidine, and hydroquinone (as the inhibitory agent) was confirmed by Fourier transform spectroscopy analysis. The setting time varied from 10 minutes to 24 hours, and the compressive strength and elastic modulus ranged from 7 to 60 MPa and 0.15 to 0.88 GPa, respectively. The results from thermometry analysis showed that the heat of reaction of the cements increased upon increasing the molar ratio of benzoyl peroxide to methyl toluene. The phase analysis of the optimized bone cement confirmed the presence of both amorphous and crystalline phases related to methyl methacrylate. Cell studies showed that the cement was non-toxic and exhibited adequate fibroblast cell adhesion. According to the results, the cement may be appropriate for the treatment of spinal damages, such as vetebroplasty and kyphoplasty.

کلیدواژه‌ها English

Polymethyl Methacrylate Bone
Cement
Liquid Phase
Mechanical Properties
Thermometry
Cytotoxicity
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مواد و فناوری‌های پیشرفته
دوره 13، شماره 4
زمستان 1403
صفحه 1-14

  • تاریخ دریافت 02 بهمن 1403
  • تاریخ بازنگری 21 بهمن 1403
  • تاریخ پذیرش 13 اسفند 1403