نوع مقاله : مقاله کامل پژوهشی
نویسندگان
1 استادیار، گروه مهندسی مواد، دانشکده مهندسی شیمی و مواد، دانشگاه صنعتی شاهرود، شاهرود، سمنان، ایران
2 کارشناسی ارشد سرامیک، گروه مهندسی مواد، دانشکده مهندسی شیمی و مواد، دانشگاه صنعتی شاهرود، شاهرود، سمنان، ایران
چکیده
در این تحقیق، نانوذرات ولاستونیت سنتز و در دماهای گوناگون کلسینه شدند. ذرات حاصله به پلیمر ژلاتین حاوی دارو افزوده شد و نانوکامپوزیت ژلاتین/ولاستونیت بهعنوان حامل داروی جنتامایسین تهیه شد. ساختار و ریختشناسی ذرات و کامپوزیتهای تهیهشده بهکمک آنالیزهای پراش پرتو ایکس (XRD)، طیفسنجی مادون قرمز (FTIR)، میکروسکوپ الکترونی روبشی نشر میدانی (FESEM) و میکروسکوپ الکترونی عبوری (TEM) ارزیابی شدند. نتایج حاصله نشاندهنده سنتز نانوذرات تکفاز ولاستونیت با اندازهای کوچکتر از 10 نانومتر بود که در بعضی از نقاط حالت کلوخهای داشتند. بررسی نرخ رهایش دارو در محیط بافر فسفات با استفاده از دستگاه طیفسنجی نوری ماوراءبنفش (UV) در طول موج ماکزیمم 201 نانومتر نشاندهنده تخریب سریع کامپوزیت و آزادسازی حدود 60 درصد دارو در ساعات اولیه بود که پس از 2 روز تقریباً تمامی دارو آزاد شد. درنتیجه، میتوان گفت کامپوزیت حاصله زیستتخریبپذیر است و قابلیت استفاده بهعنوان پرکننده نواقص استخوانی و رهاسازی دارو را بهصورت موضعی دارد.
کلیدواژهها
موضوعات
عنوان مقاله [English]
Synthesis of Bioactive and Biodegradable Gelatin/Wollastonite Nanocomposite for the Delivery of Gentamicin
نویسندگان [English]
- Esmaeil Salimi 1
- Ava Sobhani 2
1 Assistant Professor, Faculty of Chemical and Materials Engineering, Shahrood University of Technology, Shahrood, Semnan, Iran
2 MSc, Faculty of Chemical and Materials Engineering, Shahrood University of Technology, Shahrood, Semnan, Iran
چکیده [English]
In this study, wollastonite nanoparticles were synthesized and calcined at different temperatures. The resulting particles were added to a polymeric gelatin containing drug, and the gelatin/wollastonite nanocomposite was prepared as a carrier for gentamicin drug. The structure and morphology of the prepared particles and composites were evaluated using X-Ray Diffraction (XRD), Fourier Transform Infrared (FTIR) Spectroscopy, Field Emission Scanning Electron Microscopy (FESEM), and Transmission Electron Microscopy (TEM). The results showed the synthesis of single-phase wollastonite nanoparticles with sizes less than 10 nanometers, which agglomerate in some regions. The drug delivery rate in phosphate buffer solution, as analyzed by UV analysis at λmax=201 nm, indicated rapid degradation of the composite, with about 60% of the drug delivered in the initial hours and complete delivery after 2 days. Therefore, it can be concluded that the resulting composite is biodegradable and has the potential to be used as filler for bone defects and local drug delivery.a
کلیدواژهها [English]
- Nanocomposite
- Wollastonite
- Drug Release
- Biodegradable Composite
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