نوع مقاله : مقاله کامل پژوهشی

نویسندگان

1 دانشجوی دکتری، پژوهشکده فناوری نانو و مواد پیشرفته، پژوهشگاه مواد و انرژی، مشکین‌دشت، البرز، کرج، ایران

2 دانشیار، پژوهشکده فناوری نانو و مواد پیشرفته، پژوهشگاه مواد و انرژی، مشکین‌دشت، البرز، کرج، ایران

3 استاد، پژوهشکده فناوری نانو و مواد پیشرفته، پژوهشگاه مواد و انرژی، مشکین‌دشت، البرز، کرج، ایران

10.30501/jamt.2022.293011.1179

چکیده

آلفا-تری‌کلسیم فسفات، به‌عنوان جزء پودری در فرآیند تهیه سیمان‌های کلسیم فسفاتی جهت بازسازی بافت سخت استفاده می‌شود. در این تحقیق، پودر مذکور از مواد اولیه نیترات کلسیم و دی‌آمونیوم هیدروژن فسفات به روش رسوب‌دهی شیمیایی سنتز شد. پودر حاصل در 1250 درجه سلسیوس تحت عملیات حرارتی قرار گرفت و در دمای محیط به‌سرعت سرد شد. نتایج آزمون پراش اشعه ایکس (XRD) و طیف‌سنجی فروسرخ تبدیل فوریه (FTIR) پودر سنتز‌شده، تشکیل فاز آلفا-تری‌کلسیم فسفات بلوری و وجود گروه‌های شیمیایی P-O را تأیید کرد. سیمان تک‌جزئی با استفاده از پودر آلفا-تری‌کلسیم فسفات و فاز مایع حاوی 5/2 درصد دی‌سدیم هیدروژن فسفات تهیه شد. سیمان حاصل با زمان گیرش اولیه 1 17 دقیقه، دارای استحکام فشاری 2 21 مگاپاسکال بود. آزمایش‌های XRD و FTIR تشکیل مقدار زیادی هیدروکسی‌آپاتیت با کمبود کلسیم را به‌عنوان محصول سیمان تأیید ‌کرد. طبق یافته‌ها، گیرش سیمان از طریق آب‌کافت پودرهای آلفا-تری‌کلسیم فسفات و تشکیل نانو‌فلس‌های هیدروکسی‌آپاتیت با کمبود کلسیم به طول تقریبی 500 نانومتر اتفاق افتاده‌است. آزمایش زیست‌فعالی، تشکیل هیدروکسی‌آپاتیت در سطح خارجی سیمان را طی 14 روز غوطه‌وری در مایع شبیه‌سازی‌شده بدن، نشان ‌داد.

کلیدواژه‌ها

موضوعات

عنوان مقاله [English]

Synthesis and characterization of alpha-tricalcium phosphate and its single-component cement

نویسندگان [English]

  • Rahim Jahandideh 1
  • Aliasghar Behnamghader 2
  • Saeed Hesaraki 3

1 PhD Candidate, Department of Nanotechnology and Advanced Materials, Materials and Energy Research Center, MeshkinDasht, Alborz, Iran

2 Associate Professor, Department of Nanotechnology and Advanced Materials, Materials and Energy Research Center, MeshkinDasht, Alborz, Iran

3 Professor, Department of Nanotechnology and Advanced Materials, Materials and Energy Research Center, MeshkinDasht, Alborz, Iran

چکیده [English]

Alpha-tricalcium phosphate can be used as a powder component in the preparation process of calcium phosphate cements in hard tissue applications. In this study, the mentioned powder was synthesized through chemical precipitation method using calcium nitrate and diammonium hydrogen phosphate as the raw materials. The resulting powder was heat-treated at 1250 °C and quenched at the ambient temperature. The results of X-Ray Diffraction (XRD) analysis and Fourier Transform Infrared (FTIR) spectroscopy confirmed the formation of crystalline Alpha-tricalcium phosphate phase and presence of P-O chemical groups, respectively. The Single-component cement was prepared using Alpha-tricalcium phosphate powder with the liquid phase containing 2.5% disodium hydrogen phosphate. The resulting cement sample had an initial setting time of 17 1 minute and the compressive strength of 21 2 MPa. The XRD and FTIR experiments revealed the formation of a great amount of calcium deficient hydroxyapatite as the resulting cement product. According to the findings, the cement setting occurred through the hydrolysis of Alpha-tricalcium phosphate powders and the formation of calcium deficient hydroxyapatite nanoflakes of approximately 500 nm in length. Finally, the cement acellular bioactivity experiment confirmed that the hydroxyapatite was formed on the outer surface of the cement during 14 days of immersion in the simulated body fluid.

کلیدواژه‌ها [English]

  • Alpha-tricalcium phosphate
  • Synthesis
  • Cement
  • Calcium deficiency hydroxyapatite
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