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بهینه‌سازی ساختارهای متخلخل بر پایه پلی‌پروپیلن فومارات/ هیدروکسی اتیل‌متاکریلات/ شیشه زیست‌فعال ساخته‌شده به روش زیست‌الهامی براساس استحکام مکانیکی و مورفولوژی سطحی

نویسندگان

1 پژوهشگاه مواد و انرژی، پژوهشکده نانوتکنولوژی و مواد پیشرفته، گروه بیومواد، کرج، ایران

2 پژوهشگاه مواد و انرژی، پژوهشکده انرژی، گروه محیط زیست و انرژی، کرج، ایران

3 دانشگاه کاشان، دانشکده شیمی، گروه شیمی تجزیه، کاشان، ایران

چکیده

این‌کار مربوط به بهینه‌سازی ساختارهای متخلخل بر پایه نانوکامپوزیت پلی‌پروپیلن فومارات/هیدروکسی اتیل متاکریلات/ نانوذرات شیشه زیست‌فعال است که با واکنش کاهش- اکسایش (پلیمریزاسیون رادیکال آزاد) در دمای اتاق شبکه‌ای شده‌اند. این ساختارها با غوطه‌وری نانوکامپوزیت‌های تهیه‌شده به مدت چهار هفته در محلول مشابه مایعات بدن ایجاد می‌شوند و بر‌اساس استحکام مکانیکی (استحکام فشاری) و مورفولوژی سطح (تصاویر میکروسکوپ الکترونی روبشی) بهینه‌سازی می-شوند. در این بهینه‌سازی اثرات نسبت پلی‌پروپیلن فومارات/ هیما، میزان نانوذرات شیشه زیست‌فعال و درصد عامل جفت آغازگر بنزوئیل پروکساید و ان و ان دی‌متیل آنیلین، در ایجاد ساختارهای متخلخل و تغییرات استحکام مکانیکی، مشخص شد. درنهایت، بهترین فرمولاسیون نانوکامپوزیتی براساس عوامل مذکور نمونه‌ای که حاوی نسبت پلی‌پروپیلن فومارات/ هیما معادل 30/70، نانوذرات شیشه زیست‌فعال به میزان 20% وزنی و جفت آغازگر معادل 5/1% وزنی بود (SPHB.732/1.5)، به‌عنوان ساختار بهینه معرفی شد. این ساختار دارای مدول الاستیکی معادل MPa 7/57، حفراتی به‌هم‌پیوسته و به‌طور کامل باز به ابعاد حدود µm 200-100 و دارای سطحی پوشیده شده با میکروذرات هیدروکسی‌کربنات آپاتیت بود. ساختار SPHB.732/1.5 تهیه‌شده به روش غوطه‌وری در مایع شبیه‌سازی شده بدن، علاوه بر زیست‌فعال بودن، زیست‌تخریب‌پذیر است و بنابراین می‌تواند به‌عنوان داربست سلول‌های استخوانی مورد ارزیابی‌های بیشتر مانند مطالعات سلولی قرار گیرد.

کلیدواژه‌ها

عنوان مقاله [English]

Optimization of Porous Structures Based on Polypropylene Fumarate /Hydroxy Ethyl Metacrylate/ Bioactive Glass Prepared by Biomimetic Methods with Mechanical Strength and Surface Morphology Analyses

نویسندگان [English]

  • Sara Shahbazi 1
  • Ali Zamanyan 1
  • Mohammad Pazouki 2
  • Yaser Jafari 3

1 Material and Energy research Center, Department of Nanotechnology and Advanced Material, Karaj, Iran

2 Material and Energy research Center, Department of Energy, Karaj, Iran

3 University of Kashan, Department of Analytical Chemistry, Kashan, Iran

چکیده [English]

This work is related to optimize the porous structure nanocomposites based on polypropylene fumarate/ hydroxyethyl methacrylate/ bioactive glass nanoparticles (PPF/HEMA/NBG) which are cross-linked through the Reduction-Oxidation reaction (free radical polymerization) at the room temperature. The porous structures prepared by immersion of the nanocomposites in simulated body fluid (SBF) for 4 weeks. The samples were optimized based on the PPF/HEMA ratio, the NBG content and percentage of the benzoyl peroxide and dimethyl aniline pairs (BPO+DMA) with mechanical strength (compressive strength) and surface morphology (SEM images) analyses. Finally, the best structure based on mentioned factors, SPHB.732/1.5, which contains the PPF/HEMA ratio at 30/70, NBG content at 20 wt% and BPO+DMA pairs at 1.5 wt% was introduced as the optimum structure. This structure has an elastic modulus of 57.7 Mpa, interconnected-open porous architecture with the pore size approximately 100-200μm and the surface coated with hydroxycarbonate apatite microparticles (HCA). The SPHB.732/1.5 structure prepared by soaking in SBF not only is a bioactive component but also is a biodegradable material and hence can be used as a bone scaffold when more evaluate for this application.

کلیدواژه‌ها [English]

  • optimization
  • Bone scaffold
  • Biomimetic
  • Surface morphology
  • Mechanical Strength
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مواد و فناوری‌های پیشرفته
دوره 6، شماره 4
اسفند 1396
صفحه 11-24
فایل ها
سابقه مقاله
  • تاریخ دریافت: 13 شهریور 1396
  • تاریخ بازنگری: 05 آبان 1396
  • تاریخ پذیرش: 17 دی 1396
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