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طراحی و ساخت داربست هیبرید چاپ سه‌بعدی پلی‌کاپرولاکتون/پلی‌لاکتیک ـ کو ـ گلایکولیک اسید حاوی نانوذرات آلژینات به‌منظور به‌کارگیری در مهندسی بافت غضروف

نوع مقاله : مقاله کامل پژوهشی

نویسندگان

1 دانشجوی دکتری، گروه مهندسی پزشکی، دانشکده فنی و مهندسی، واحد تهران مرکزی، دانشگاه آزاد اسلامی، تهران، تهران، ایران

2 استادیار، گروه سامانه‌های نوین دارورسانی، پژوهشگاه بسپار و پتروشیمی ایران، تهران، تهران، ایران

3 استادیار، گروه مهندسی پزشکی، دانشکده فنی و مهندسی، ‌واحد تهران مرکزی، دانشگاه آزاد اسلامی، تهران، تهران، ایران

4 دانشیار، گروه علوم تشریحی، دانشکده پزشکی، دانشگاه علوم پزشکی اصفهان، اصفهان، اصفهان، ایران

چکیده

مهم‌ترین راهبرد در مهندسی بافت، ارتباط بین سه جزء زیست‌ماده، یاخته‌های زنده و مولکول‌های فعال زیستی به‌منظور ساخت محیط‌ های نسخه‌برداری‌شده از شرایط بافت آسیب‌دیده و سپس ‌ترویج بافت با هدف ترمیم و بازسازی است. برای اثرگذاری بالینی، این محیط‌ ها باید تا حد امکان ویژگی‌های اصلی ماتریس خارج یاخته‌ای (ECM) را در مقیاس یاخته‌ای تکرار کنند. مهندسی بافت توانسته است داربست‌های هیبریدی را برای حمایت از بازسازی بافت غضروف با استفاده از روش‌های چاپ ‌سه‌بعدی طراحی کند. در این مطالعه، داربست‌های ‌سه‌بعدی با استفاده از پلی‌کاپرولاکتون/پلی‌لاکتیک ـ کو ـ گلیکولیک اسیدِ (PCL/PLGA) موردتأیید FDA طراحی شدند. در ادامه، نانوذرات آلژینات با غلظت‌های 40 و 45 (درصدوزنی)، به‌منظور بهبود چاپ‌پذیری، خواص مکانیکی و بررسی زیست‌سازگاری داربست‌ها، به جوهر زیستی اضافه شد. درنهایت، داربست‌های چاپ سه‌بعدی‌، براساس خواص مکانیکی، میزان آب‌دوستی سطح، میزان جذب آب، زیست‌تخریب‌پذیری، ریخت‌شناسی سطوح و میزان مانایی یاخته‌ای ارزیابی شدند. نتایج نشان داد که افزایش درصد نانوذرات آلژینات در جوهر زیستی سبب افزایش درصد تخلخل‌ها، آب‌دوستی سطح، افزایش خواص مکانیکی، مانایی یاخته و قابلیت چاپ‌پذیری می‌شود. همچنین، نتایج نشان داد که جذب آب و مدول‌ فشاری در داربست‌های PCL/PLGA چاپ ‌سه‌بعدی‌ حاوی 45 درصد نانوذرات آلژینات، بهینه‌تر از گروه‌های دیگر است و این جوهر زیستی می‌تواند در چاپ ‌سه‌بعدی داربست‌های به‌کاررفته برای رفع نواقص مهندسی بافت استفاده شود.

کلیدواژه‌ها

موضوعات

عنوان مقاله [English]

E-Design and Fabrication of 3D-Printed Polycaprolactone/Poly Lactic-co-Glycolic Acid Hybrid Scaffold Containing Alginate Nanoparticles for Cartilage Tissue Engineering Applications

نویسندگان [English]

  • Babak Pourmollaabbassi 1
  • Hamid Mahdavi 2
  • Shahrokh Shojaee 2
  • Hossien Salehi Rozveh 3
  • Ali Valiani 4

1 Ph. D. Student, Department of Biomedical Engineering, Central Tehran Branch, Islamic Azad University, P. O. Box:13185/768, Tehran, Tehran, Iran

2 Assistant Professor, Department of Novel Drug Delivery Systems, Iran Polymer and Petrochemical Institute, Tehran, Tehran, Iran

3 Associate Professor, Department of Anatomical and Molecular Biology Sciences, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Isfahan, Iran

4 Associate Professor, Department of Anatomical and Molecular Biology Sciences, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Isfahan, Iran

چکیده [English]

Abstract     The most important strategy in tissue engineering is the relationship between the three components of biomaterials, living cells, and biologically active molecules suitable for tissue regeneration. To be clinically effective, these environments must replicate, as closely as possible, the main characteristics of the native Extracellular Matrix (ECM) on a cellular scale. Tissue engineering is generally employed to create hybrid scaffolding to support cartilage tissue regeneration using fabrication 3D printing techniques. The current study designed a three-dimensional scaffold using FDA-approved Polycaprolactone/Poly Lactic-co-Glycolic Acid (PCL/PLGA) polymers. Then, 40 and 45 (w/w) alginate nanoparticles were added to the bio-ink to improve the printability, mechanical properties, and biocompatibility of the scaffolds. Finally, 3D-printed scaffolds were evaluated using mechanical properties, surface hydrophilicity, water absorption, biodegradability, surface morphology, and cell viability. The results showed that increasing the percentage of alginate nanoparticles in the bio-ink would increase the percentage of porosity, surface hydrophilicity, mechanical properties, cell viability, and printability. In addition, water absorption and compression modules of PCL/PLGA 3D-printed scaffolds containing 45 % alginate were optimized, compared to those of other groups, hence used as bio-ink in 3D printing of scaffolds in tissue engineering defects.

کلیدواژه‌ها [English]

  • 3D Printing
  • Alginate
  • Polycaprolactone
  • Polylactic Acid
  • Tissue Engineering
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مواد و فناوری‌های پیشرفته
دوره 11، شماره 3
آذر 1401
صفحه 57-74
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  • تاریخ دریافت: 08 دی 1400
  • تاریخ بازنگری: 17 بهمن 1400
  • تاریخ پذیرش: 14 اسفند 1400
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