نوع مقاله : مقاله کامل پژوهشی

نویسندگان

1 دانشجوی کارشناسی ارشد، آزمایشگاه بیومواد، گروه مهندسی و علوم زیستی، دانشکده علوم و فنون نوین، دانشگاه تهران، تهران، تهران، ایران

2 استادیار، آزمایشگاه بیومواد، گروه مهندسی و علوم زیستی، دانشکده علوم و فنون نوین، دانشگاه تهران، تهران، تهران، ایران

چکیده

نانوذرات اکسید روی از دو مسیر متفاوت از طریق فرایند رسوب ­نشانی سنتز شدند و تأثیر متغیرهای فرایند بر ساختار، اندازه و خواص ضدباکتریایی نانوذرات بررسی شد. ریخت­ شناسی و ساختار بلوری به­ وسیله میکروسکوپ الکترونی روبشی نشر میدانی (FESEM) و پراش پرتو ایکس (XRD) مطالعه شد. تصاویر FESEM نشان داد نانوذرات سنتز­شده بدون عامل پایدارکننده و در دمای عملیات حرارتی بالاتر، دارای اندازه ذرات در محدوده 120-20 نانومتر بودند؛ درحالی‌که اندازه نانوذرات سنتزشده با عامل پایدارکننده در دمای پایین ­تر در محدوده 70-10 نانومتر قرار داشت. از مسیر سنتز حاوی عامل پایدارکننده برای ورود یون مس استفاده شد. نتایج پراش پرتو ایکس نشان داد افزودن مقادیر کم یون مس (Zn0.97Cu0.03O) منجر به ورود این یون در ساختار بلوری اکسید روی خواهد شد؛ درحالی­که در مقادیر بالاتر (Zn0.95Cu0.05O)، علاوه‌بر اکسید روی، فاز اکسید مس نیز تشکیل می­ شود. آزمون ضدباکتریایی در برابر باکتری گرم مثبت استافیلوکوکوس اورئوس نشان داد که نانوذرات اکسید روی دوپ­ شده با غلظت پایین یون مس، از فعالیت ضدباکتریایی بالاتری برخوردارند؛ بنابراین، نانوذرات اکسید روی دوپ ­شده با یون مس می­توانند به‌عنوان عامل ضدباکتریایی جدید در کاربردهای پزشکی مورد استفاده قرار گیرند.
 

کلیدواژه‌ها

موضوعات

عنوان مقاله [English]

Effect of Copper Ion Incorporation on Structure and Antibacterial Properties of ZnO Nanoparticles

نویسندگان [English]

  • Farzaneh Naseriyan 1
  • Abdorreza S. Mesgar 2
  • Zahra Mohammadi 2

1 M. Sc. Student, Biomaterials Laboratory, Department of Life Science and Engineering, Faculty of New Sciences and Technologies, University of Tehran, Tehran, Tehran, Iran

2 Assistant Professor, Biomaterials Laboratory, Department of Life Science and Engineering, Faculty of New Sciences and Technologies, University of Tehran, Tehran, Tehran, Iran

چکیده [English]

Zinc oxide nanoparticles through precipitation method as a cost-effective and flexible process by two different routes were synthesized. The effect of process parameters on the structure, particle size and antibacterial properties of nanoparticles was investigated by using FESEM, XRD and antibacterial test. FESEM micrographs showed that the nanoparticles synthesized at higher heat treatment temperature without the use of stabilizing agent have particle size within 20-120 nm but those synthesized using stabilizing agent at lower heat treatment temperature have a smaller size in the range of 10-70 nm. In other to incorporate copper into the ZnO structure, the stabilizing agent-containing route was used. The XRD results showed that the use of low concentration of copper led to incorporation of Cu into the ZnO structure. However, two phases of copper oxide and zinc oxide were formed when the higher concentration of copper was used. The antibacterial test against gram-positive bacteria Staphylococcus aureus proved the higher antibacterial activity of the copper doped zinc oxide. The findings indicate that the copper doped zinc oxide nanoparticles may be a good candidate of antibacterial agent for biomedical applications.

کلیدواژه‌ها [English]

  • ZnO nanoparticles
  • Cu-doped ZnO
  • Antibacterial agent
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