Authors
1 Department of Material, University of Semnan, Semnan, Iran
2 Department of Biomaterials, nanotechnology and tissue engineering, Advanced Medical Technology Department, Isfahan University of Medical Sciences, Isfahan, Iran
3 Department of Biomedical engineering, Faculty of engineering, University of Isfahan, Isfahan, Iran
4 Department of Textile Engineering, Isfahan University of Technology, Isfahan, Iran
Abstract
Recently, composite scaffolds prepared by electrospinning have shown desirable properties for tissue engineering applications. In this study, first the nBGs were prepared via the sol-gel technique, then, the electrospun PHB/nBG nanocomposite scaffolds (with 7.5, 10 and 15 wt% of nBGs) were fabricated. The nanoparticles and scaffolds were characterized by Scanning Electron Microscopy (SEM), X-ray diffraction spectrometer (XRD), X-rayfluorescence spectroscopy (XRF), Fourier transform infrared spectroscopy (FTIR). Results showed that nanoparticles with an
amorphous structure mainly had a particle size of less than 70 nm. All the nano-fibrous scaffolds had a uniform
distribution of interconnected porosities with fiber diameters ranging from 326.1 nm to 1.276 micrometer. Composite
scaffolds having nanoparticle concentrations higher than 7.5 wt%, tend to agglomerate. In addition, the FTIR results
showed a favorable interaction between the polymer and nBGs. Therefore, the proposed PHB/nBG scaffolds prepared
in this study can be considered as good candidates for bone tissue engineering applications
Keywords
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