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Synthesis of Bioactive and Biodegradable Gelatin/Wollastonite Nanocomposite for the Delivery of Gentamicin

Document Type : Original Reaearch Article

Authors

1 Assistant Professor, Faculty of Chemical and Materials Engineering, Shahrood University of Technology, Shahrood, Semnan, Iran

2 MSc, Faculty of Chemical and Materials Engineering, Shahrood University of Technology, Shahrood, Semnan, Iran

Abstract

In this study, wollastonite nanoparticles were synthesized and calcined at different temperatures. The resulting particles were added to a polymeric gelatin containing drug, and the gelatin/wollastonite nanocomposite was prepared as a carrier for gentamicin drug. The structure and morphology of the prepared particles and composites were evaluated using X-Ray Diffraction (XRD), Fourier Transform Infrared (FTIR) Spectroscopy, Field Emission Scanning Electron Microscopy (FESEM), and Transmission Electron Microscopy (TEM). The results showed the synthesis of single-phase wollastonite nanoparticles with sizes less than 10 nanometers, which agglomerate in some regions. The drug delivery rate in phosphate buffer solution, as analyzed by UV analysis at λmax=201 nm, indicated rapid degradation of the composite, with about 60% of the drug delivered in the initial hours and complete delivery after 2 days. Therefore, it can be concluded that the resulting composite is biodegradable and has the potential to be used as filler for bone defects and local drug delivery.a

Keywords

Main Subjects

References
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Journal of Advanced Materials and Technologies
Volume 12, Issue 4
January 2024
Pages 48-60
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