Preparation of Nanocomposite Fibrous Scaffolds of Poly-3-hydroxybutyrate/Bioactive Glass by Electrospinning Method for Bone Tissue Engineering

Iron, R.; Karbasi, S.; Mehdikhani, M.; Semnani, D.

doi:10.30501/jamt.2635.70278

Preparation of Nanocomposite Fibrous Scaffolds of Poly-3-hydroxybutyrate/Bioactive Glass by Electrospinning Method for Bone Tissue Engineering

Authors

R. Iron ¹

S. Karbasi ²

M. Mehdikhani ³

D. Semnani ⁴

¹ Department of Material, University of Semnan, Semnan, Iran

² Department of Biomaterials, nanotechnology and tissue engineering, Advanced Medical Technology Department, Isfahan University of Medical Sciences, Isfahan, Iran

³ Department of Biomedical engineering, Faculty of engineering, University of Isfahan, Isfahan, Iran

⁴ Department of Textile Engineering, Isfahan University of Technology, Isfahan, Iran

10.30501/jamt.2635.70278

Abstract

Recently, composite scaffolds prepared by electrospinning have shown desirable properties for tissue engineering applications. In this study, first the nBGs were prepared via the sol-gel technique, then, the electrospun PHB/nBG nanocomposite scaffolds (with 7.5, 10 and 15 wt% of nBGs) were fabricated. The nanoparticles and scaffolds were characterized by Scanning Electron Microscopy (SEM), X-ray diffraction spectrometer (XRD), X-rayfluorescence spectroscopy (XRF), Fourier transform infrared spectroscopy (FTIR). Results showed that nanoparticles with an
amorphous structure mainly had a particle size of less than 70 nm. All the nano-fibrous scaffolds had a uniform
distribution of interconnected porosities with fiber diameters ranging from 326.1 nm to 1.276 micrometer. Composite
scaffolds having nanoparticle concentrations higher than 7.5 wt%, tend to agglomerate. In addition, the FTIR results
showed a favorable interaction between the polymer and nBGs. Therefore, the proposed PHB/nBG scaffolds prepared
in this study can be considered as good candidates for bone tissue engineering applications

Keywords

Tissue engineering

Electrospinning

Sol-gel

Bioactive glass nanoparticles

polyhydroxybutyrate

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