Journal of Advanced Materials and Technologies

Journal of Advanced Materials and Technologies

Evaluation of bioactivity poly-3-hydroxybutyrate coated Nano-Bioglass 45S5 composite scaffolds for bone tissue engineering

Authors
M. Montazeri 1
S. Karbasi 2
A. Monshi 3
R. Ebrahimi-kahrizsangi 1
1 Department of Material engineering, University of Najafabad, City Esfahan, Country Iran
2 Department of Biomaterials, nanotechnology and tissue engineering, Advanced Medical Technology Department, Isfahan University of Medical Sciences, City Esfahan, Iran
3 Department of Material engineering, Isfahan University of technology, City Esfahan, Country Iran
10.30501/jamt.2010.70229
Abstract
Development of composite scaffolds due to combing useful properties of two or more materials in order to meet mechanically and physiologically host tissue is increasing. Firstly, nano-Bio glass (nBG) powder was made with grain size between 55-65nm and then porous nBG of 30, 40 and 50%wt was produced by polyurethane sponge replication method. In order to increase the scaffoldsmechanical properties, they coated with 6%wt poly-Hydroxybutyrate (P3HB) for 30sec and 1min. XRD,XRF, SEM, FE-SEM and FT-IR were used in order to study the phase and elemental structure , morphology , grain size and functional groups , respectively. The scaffold including 30%wt nBG and 6%wt was used for evaluation of bioactivity. Biocompatibility of the scaffold was also tested in SBF solution for 4 weeks at 37 ºC. XRD ,SEM and AAS results showed formation of HA on the surface of scaffold which prove the its biocompatibility, the result is showing that, the best scaffold is 30%wt nBG /6%wt P3HB with 75-87% porosity, which is a good candidate for bone tissue engineering.
Keywords
Bioglass 45S5
composite scaffolds
P3HB
Bone tissue engineering
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Journal of Advanced Materials and Technologies
Volume 2, Issue 4
Winter 2013
Pages 10-18

  • Receive Date 30 September 2013
  • Revise Date 15 December 2013
  • Accept Date 15 December 2013