In this study, dissolvable microneedle (MN) arrays based on polyvinyl alcohol (PVA) were designed, fabricated, and evaluated for the controlled transdermal delivery of curcumin (Cur@MN). Fourier-Transform Infrared Spectroscopy (FTIR) confirmed the incorporation of curcumin within the PVA matrix, as evidenced by the presence of three characteristic peaks at 1510 cm⁻¹, 1603 cm⁻¹, and 1628 cm⁻¹. Optical and scanning electron microscopy revealed uniformly arranged, conical microneedles with sharp tips (<15 µm). Mechanical testing demonstrated successful penetration of five layers of Parafilm, indicating sufficient insertion strength for transdermal application. Drug release and degradation studies were conducted in phosphate-buffered saline (PBS, pH 7.4). The release profile exhibited an initial burst (60.31% within 12 hours), followed by sustained release up to 72 hours, reaching a cumulative release of 82.5%. Degradation tests showed faster structural breakdown in curcumin-loaded microneedles compared to unloaded ones. Furthermore, DPPH radical scavenging assays confirmed the significant antioxidant activity of Cur@MN, particularly at higher concentrations. These findings suggest that Cur@MN microneedles offer a promising, biocompatible platform for the transdermal delivery of natural therapeutics such as curcumin.
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Koohikar,A. and Mehdinavaz Aghdam,R. (2025). Microfabrication and Characterization of PVA-Based Microneedle Arrays for Curcumin Delivery. Journal of Advanced Materials and Technologies, 14(2), 76-89. doi: 10.30501/jamt.2025.523415.1331
MLA
Koohikar,A. , and Mehdinavaz Aghdam,R. . "Microfabrication and Characterization of PVA-Based Microneedle Arrays for Curcumin Delivery", Journal of Advanced Materials and Technologies, 14, 2, 2025, 76-89. doi: 10.30501/jamt.2025.523415.1331
HARVARD
Koohikar A., Mehdinavaz Aghdam R. (2025). 'Microfabrication and Characterization of PVA-Based Microneedle Arrays for Curcumin Delivery', Journal of Advanced Materials and Technologies, 14(2), pp. 76-89. doi: 10.30501/jamt.2025.523415.1331
CHICAGO
A. Koohikar and R. Mehdinavaz Aghdam, "Microfabrication and Characterization of PVA-Based Microneedle Arrays for Curcumin Delivery," Journal of Advanced Materials and Technologies, 14 2 (2025): 76-89, doi: 10.30501/jamt.2025.523415.1331
VANCOUVER
Koohikar A., Mehdinavaz Aghdam R. Microfabrication and Characterization of PVA-Based Microneedle Arrays for Curcumin Delivery. J. Adv. Mater. Technol., 2025; 14(2): 76-89. doi: 10.30501/jamt.2025.523415.1331
