Journal of Advanced Materials and Technologies

Journal of Advanced Materials and Technologies

Fabrication and Characterization of L-Glutamine-Functionalized Magnetic Graphene Oxide as a Novel Bio-Platform for Controlled Release of 5-Fluorouracil

Document Type : Original Reaearch Article

Authors
Mohammad Sharifpour 1
Mahsasadat Miralinaghi 2
1 MSc Student, Department of Chemical Engineering, Science and Research Branch, Islamic Azad University, Tehran, Iran.
2 Associate Professor, Department of Chemistry, Faculty of Science, Varamin - Pishva Branch, Islamic Azad University, Varamin, Iran.
10.30501/jamt.2023.408409.1283
Abstract
Surface modification with biomolecules can overcome Graphene Oxide (GO) restrictions in biocompatibility, cellular internalization, and drug delivery effectiveness, hence  suitable for a wide range of biomedical applications. In this study, a biocomposite (L-glutamine-functionalized magnetic graphene oxide (L-Gln/MGO)) was prepared and used as a suitable nanoscale carrier with high drug loading capacity and excellent release properties for 5-fuorouracil (5FU), an anticancer drug. The optimum pH for maximum drug adsorption was determined as 4 at 293 K and as the temperature increased, the adsorption capacity decreased due to the exothermic nature of the adsorption process. Some well-known models, including pseudo-first-order, pseudo-second-order, and Intraparticular Diffusion (IPD), were applied to examine the kinetics of adsorption. Additionally, the Langmuir, Freundlich, and Redlich-Peterson models were used to investigate the adsorption isotherms. The obtained results showed that the adsorption process adhered to the Langmuir isotherm and pseudo-second-order kinetic models. Nearly 26% of 5FU was released in the simulated stomach fluid at the pH of 1.2 and temperature of 37 °C in the first 30 minutes while 32% of which was released in the simulated intestinal fluid at the pH of 7.4 during the next 30 hours. The obtained results might be helpful for designing a controllable loading and targeted 5FU drug delivery system.
Keywords
Nanocomposite
Adsorption
Controlled Release
Targeted Drug Delivery

Subjects

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Journal of Advanced Materials and Technologies
Volume 12, Issue 4
Winter 2024
Pages 24-37

  • Receive Date 23 July 2023
  • Revise Date 14 August 2023
  • Accept Date 27 September 2023