Journal of Advanced Materials and Technologies

Journal of Advanced Materials and Technologies

Synthesis of Polycaprolactam/Zinc Doped Hydroxyapatite Nanofibers via Electrospinning

Authors
H. Esfahani
E. Salahi
S.A. Tayebifard
M.R. Rahimipour
Mansoor Kianpour
Materials and Energy Research Center (MERC), Karaj, Iran
10.30501/jamt.2635.70273
Abstract
In this study Nanofibers of polycaprolactam (Nylon 6)/zinc doped hydroxyapatite (HAP) were synthesized via
electrospinning method. Hydroxyapatite nanoparticles containing 4 at % zinc were synthesized via chemical
precipitation method. XRD and FTIR of the synthesized powders indicated that non-stoichiometric and single phase
hydroxyapatite was formed. The results also showed that Zn cations have been incorporated in atomic structure of HAP.
The average of particle size and crystallite were calculated 43 and 16 nm respectively. Polymeric solution was prepared
throughout dissolving of 20 wt% polycaprolactam in formic acid. To synthesize the composite nonofibers, 2 wt% of
synthesized ceramic powders were added to polymeric solution. Influence of voltage (15-30 kV) and flow rate (0.1-0.5
ml.h-1) on diameter and morphology of nanofibers were investigated. The results of SEM images showed that fibers
with average diameter of 100-300 nm were formed, and also zinc doped hydroxyapatite particles were homogenously
distributed between nano fibers. The results indicated that increasing of the applied voltage over 30 kV caused to
romaine ticker fibers as ribbon shaped. Results also showed that the average of fiber diameter increased with decreasing
the flow rate resulting in heterogeneous distribution of HAp nanoparticles. The agrigate of Zn doped HAP was formed
separately when the flow rate was set to 0.1 ml.h-1.

Keywords
Electrospinning
Hydroxyapatite
Nanofiber
Zinc Doping
  1. Wang, A. Lajevardi-Khosh, S. Choi, J. Cha, Regenerative surface plasmon resonance (SPR) biosensor: Real-time measurement of fibrinogen in undiluted human serum using the competitive adsorption of proteins,Biosens. Bioelectron. 28(2011) 304-307.
  2. A. Chen, R.G. Carbonell, G.A. Serad, Recovery of proteins and other biological compounds from food processing wastewaters using fibrous materials and polyelectrolytes, Water. Res., 34(2000) 510-518.
  3. Zhang, X. Jia, F. Han, J. Zhao, Y. Zhao, Y. Fan, X. Yuan, Dual-delivery of VEGF and PDGF by double-layered electrospunmembranes for blood vessel regeneration, Biomaterials. 34 (2013) 2202-2212.
  4. M.A. Shirazi, A. Kargari, S. Bazgir, M. Tabatabaei, M.J.A. Shirazi, M.S. Abdullah, T. Matsuura, A.F. Ismail, Characterization of electrospun polystyrene membrane for treatment of biodiesel's water-washing effluent using atomic force microscopy, Desalination. 329 (2013) 1-8.
  5. Fang Jian, Niu HaiTao, Lin Tong and Wang XunGai., Applications of electrospun nanofibers, Chinese Science Bulletin, 2008, 2265-2286.
  6. Tatsuya Okuyama, Hirotaka Maeda and Emile Hideki Ishida, Preparation of porous poly(L-lactic acid)/tobermorite composite membranes via electrospinning and heat treatment, J Mater Sci, 10853, 2011, 5834-8.
  7. Kai Zhang, Man Zhao, Lei Cai, Zheng-ke Wang, Yong-fu Sun and Qiao-ling Hu., Preparation of chitson/hydroxyapatite gided membrane used for periodontal tissue regeneration, Chinese Journal of Polymer Science Vol. 28, No. 4, 2010, 555−561.
  8. A. Salifu, B. D. Nury, and C. Lekakou., Electrospinning of Nanocomposite Fibrillar Tubular and Flat Scaffolds with Controlled Fiber Orientation, Annals of Biomedical Engineering,39, 10, 2011, 2510–2520.
  9. Zhao Ma, Feng Chen, Ying-Jie Zhu, Ting Cui and Xuan-Yong Liu., Amorphous calcium phosphate/poly(D,L-lactic acid) composite nanofibers, Electrospinning preparation and biomineralization, Journal of Colloid and Interface Science, 359, 2011, 371–379.
  10. Huan Zhou, Ahmed H. Touny, Sarit B. Bhaduri., Fabrication of novel PLA/CDHA bionanocomposite fibers for tissue engineering applications via electrospinning, J Mater Sci: Mater Med, 22, 2011, 1183–1193.
  11. منصور کیانپورراد، کاپرولاکتام و تولید آن به­وسیله شار تابش مستقیم خورشیدی، نشریه شیمی و مهندسی شیمی ایران، سال هفدهم،1377، 157-163.
  12. Labet Marianne; Thielemans, Wim. Synthesis of polycaprolactone: a review, Chemical society reviews, 38, 2009, 3484-3504.
  13. Y. Gan, Z.H. Shang, J. D.Wang, New affinity nylon membrane used for adsorption of g-globulin, J. Chromatogr. A. 867 (2000) 161–168.
  14. Xia, G. Zhang, F. Zhang, Bilirubin removal by Cibacron Blue F3GA attached nylon-based hydrophilic affinity membrane, J. Membrane. Sci.226 (2003) 9–20.
  15. Keizer and H.Verweij, Ph.D thesis, Progress in inorganic membranes, University Of Twente (The Netherlands and VITO (Belgium), 1996.
  16. Vanholder R, De Smet R, Vogeleere P, Hsu CH, Ringoir SM, The uraemic syndrome, in Replacement of renal function by dialysis, edited by Jacobs C, Kjellstrand CM, Koch KM, Winchester JF, 4th ed, Dordrecht, Kluwer Academic Publisher, 1996, 103-113.
  17. Beuchat C.A., Metabolism and the scaling of urine concentrating ability in mammals: resolution of a paradox? J Theor Biol 143: 1990, 113–122.
  18. D. Cullity and Bernard Dennis, diffraction, directions of diffracted beams, elements of X-ray diffraction, pp. 81-106, 2001, Third edition, Addison-Wesley.
  19. Miyaji, Y. Kono, Yoko S., Formation and structure of zinc-substituted calcium hydroxyapatite, Mater. Res. Bull. 40 (2005) 209–220.
  20. Kannan, J.M. Ventura, J.M.F. Ferreira, Aqueous precipitation method for the formation of Mg-stabilized β-tricalcium phosphate: An X-ray diffraction study, J. Ceram Int. 33 (4) (2007) 637-641.
  21. Y. Zhou, Y.R. Jiang, C.C. Li, X.Y. Xie, Synthesis of poly(ethylene glycol)-functionalized hydroxyapatite organic colloidintended for nanocomposites, Chinese. Chem. Lett. 24 (2013) 647–650.
  22. Hem Raj Panta, Chan Hee Parka, Leonard D. Tijing , Altangerel Amarjargala, Do-Hee Leea, Cheol Sang Kima, Bimodal fiber diameter distributed graphene oxide/nylon-6 compositenanofibrous mats via electrospinning, Colloids and Surfaces A: Physicochem. Eng. Aspects, 407 (2012) 121– 125.

  • Receive Date 03 December 2013
  • Revise Date 23 July 2014
  • Accept Date 28 July 2014