Journal of Advanced Materials and Technologies

Journal of Advanced Materials and Technologies

Fabrication and Characterization of Xanthan Film Containing Spirulina Extract with Continues Release Capability for Use in Wound Healing

Document Type : Original Reaearch Article

Authors
Afrouz Ghasemzadeh 1
Rana Imani 2
Tahura Ebrahimi 3
1 BSc Student, Biomedical Engineering Department, Amirkabir University of Technology (Tehran Polytechnic), Tehran, Iran.
2 Assistant Professor, Biomedical Engineering Department, Amirkabir University of Technology (Tehran Polytechnic), Tehran. Tehran, Iran.
3 PhD Candidate, Biomedical Engineering Department, Amirkabir University of Technology (Tehran Polytechnic), Tehran. Iran
10.30501/jamt.2023.364845.1272
Abstract
Today, the most common method for wound treatment is to use engineered wound dressings. In the present study, a film wound dressing based on xanthan biopolymer, containing niosomal nanocarrier, was prepared for the local release of spirulina algae extract. Niosomal nanocarriers containing the spirulina extract were prepared using thin film hydration method. Then, a film wound dressing was produced by uniformly combining xanthan, glycerol emollient, and niosomes containing spirulina. According to scanning electron microscopy, the morphology of the niosomes were spherical with an average size of about 200 nm, and the percentage of drug loading within the niosomes was 72%. Moreover, 25% of the drug was released from the structure of the film containing niosomes within 20 days. Additionally, the wound dressing containing niosomes exhibited a 35% weight loss within 20 days. Through cytotoxicity testing conducted within 24 hours, it was revealed that up to a concentration of 200 μg/ml of the spirulina drug, cell viability remained higher than 80% compared to the control sample. In summary, the results of this study indicate that the niosomal carrier within the xanthan film structure could serve as an effective local drug delivery system for wound treatment.
Keywords
Wound Dressing
Xanthan Gum
Spirulina Extract
Controlled Release
Niosome
Subjects
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  • Receive Date 09 April 2023
  • Revise Date 15 July 2023
  • Accept Date 26 December 2023